Anticholinergic medication

Anticholinergic medication impairs lung function in humans (-47.2 ml/year (low exposure) vs -37.2 ml/year (unexposed)).

“participants with low and high exposure lose 47.2 ml/year (95% CI [42.4; 52.0]) and 43.7 ml/year (95% CI [25.4; 62.0])”

Humansolder adults

Association of systemic anticholinergic medication use and accelerated decrease in lung function in older adults

Scientific reports·22 Feb 2024

Anticholinergic medication is associated with cognitive decline in humans (B=0.16, R 2 Change=0.02, p < .01).

“dimensional ratings of cognitive decline were significantly associated with anticholinergic potency in both samples after accounting for the effects of age and assigned‐sex‐at‐birth (independent: B=0.16, R 2 Change=0.02; dependent: B=0.18, R 2 Change=0.03; p s < .01).”

Humansindependent autistic adultsn = 210

Reports of elevated cognitive decline in autistic adults are linked to high anticholinergic potency

AAIC 2025 abstract·24 Dec 2025