Hippocampal NR4A1 expression

1. Age is associated with hippocampal NR4A1 expression in mice.

   “in SAMP8 mice, Nr4a1 expression increased in an age-dependent manner”

   AnimalsSAMP8 micehippocampus

   Age-dependent elevation of Nr4a1 attenuates PI3K/AKT/GSK3β pathway and mediates tau hyperphosphorylation and cognitive impairments

   Journal of advanced research·16 Jun 2025

1. Alzheimer's disease is associated with hippocampal NR4A1 expression in humans.

   “Our findings revealed that Nr4a1 expression is elevated in the hippocampus of Alzheimer's patients”

   HumansAlzheimer's diseasehippocampus

   Age-dependent elevation of Nr4a1 attenuates PI3K/AKT/GSK3β pathway and mediates tau hyperphosphorylation and cognitive impairments

   Journal of advanced research·16 Jun 2025

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