Frontiers in Immunology
Human gene variant alters brain immune responses in aging mice
An experiment in male and female mice aged 6, 9 and 15 months found brain immune changes; behavioral impairments were most pronounced in older females.An experiment in male and female mice aged 6, 9 and 15 months found brain immune changes; behavioral impairments were most pronounced in older females.
Mouse studyImmune response
Who was studiedMale and female mice, against unmodified controls
What changedMice carrying the human gene variant showed progressive microglial immune changes and increased oxidative stress compared with unmodified controls
The catchMales retained their behavioral performance at all ages tested