Hippocampal cerebrovascular reactivity

1. Hippocampal cerebrovascular reactivity has no effect on white matter hyperintensities in humans.

   “There were no significant associations between hippocampal CVR and white matter hyperintensities.”

   Humansbrainn = 163

   The Relationship Between Hippocampal Cerebrovascular Reactivity and Brain Structure in Older Age

   Human brain mapping·15 Feb 2026

More on White matter hyperintensities

1. Hippocampal cerebrovascular reactivity is associated with changes in white matter integrity in humans.

   “Lower hippocampal CVR was also associated with greater changes in white matter integrity in the corpus callosum, internal capsule, and cingulum bundle between Waves 1 and 2.”

   Humansbrainn = 163

   The Relationship Between Hippocampal Cerebrovascular Reactivity and Brain Structure in Older Age

   Human brain mapping·15 Feb 2026

1. Hippocampal cerebrovascular reactivity is associated with white matter microstructural integrity in humans.

   “Lower hippocampal CVR was associated with lower left hippocampal volume, as well as lower fractional anisotropy, higher mean, radial, and axial diffusivity in the corpus callosum, internal capsule, and fornix at Wave 2.”

   Humansbrainn = 163

   The Relationship Between Hippocampal Cerebrovascular Reactivity and Brain Structure in Older Age

   Human brain mapping·15 Feb 2026

1. Hippocampal cerebrovascular reactivity is associated with left hippocampal volume in humans.

   “Lower hippocampal CVR was associated with lower left hippocampal volume”

   Humansbrainn = 163

   The Relationship Between Hippocampal Cerebrovascular Reactivity and Brain Structure in Older Age

   Human brain mapping·15 Feb 2026