1 paper
A cross-sectional study of 30 healthy adults linked older age to brain scan measures suggesting impaired fluid clearance and altered barrier function.A cross-sectional study of 30 healthy adults linked older age to brain scan measures suggesting impaired fluid clearance and altered barrier function.
An analysis of three published datasets, validated in 15 human skin samples, identified an aging-linked subgroup of cells that support small blood vessels.An analysis of three published datasets, validated in 15 human skin samples, identified an aging-linked subgroup of cells that support small blood vessels.
In 503 retired adults in China, each 0.1-micrometre rise in a marker of vessel lining damage was linked to 12% higher odds of asymptomatic heart dysfunction.In 503 retired adults in China, each 0.1-micrometre rise in a marker of vessel lining damage was linked to 12% higher odds of asymptomatic heart dysfunction.
In 86 adults, brain scans showed widespread white matter changes, while older people relied on different nerve pathways than younger adults for executive tasks.In 86 adults, brain scans showed widespread white matter changes, while older people relied on different nerve pathways than younger adults for executive tasks.
In a laboratory experiment, chemically induced senescent human retinal cells showed increased mobility and altered binding of proteins that anchor DNA to the nuclear…In a laboratory experiment, chemically induced senescent human retinal cells showed increased mobility and altered binding of proteins that anchor DNA to the nuclear scaffold.
Young and 18-month-old mice with an altered UCHL1 protein showed less white matter injury and better sensorimotor and cognitive performance in a dementia model.Young and 18-month-old mice with an altered UCHL1 protein showed less white matter injury and better sensorimotor and cognitive performance in a dementia model.
Among 5,230 adults aged 45 and older followed for a median 9.8 years, one brain diffusion marker best predicted cognitive decline, while two best predicted dementia risk.Among 5,230 adults aged 45 and older followed for a median 9.8 years, one brain diffusion marker best predicted cognitive decline, while two best predicted dementia risk.
An observational comparison of 54 healthy older and 28 younger adults linked slower stepping to less efficient information processing, rather than greater caution.An observational comparison of 54 healthy older and 28 younger adults linked slower stepping to less efficient information processing, rather than greater caution.