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High frailty

There is 1 paper on high frailty in aging research: 1 observational study in people. The newest story, Oct 26, 2026: “Illness burden’s link to death is weaker with frailty in heart failure”.

Biomarker

1 paper studies it241 more mention it2 findings

8 new papers in 30 daysSee all 242

“HF (AOR 3.3; 95 % CI, 2.7-4.1) were associated with greater odds of in-hospital mortality.”
Association of frailty with clinical and financial outcomes of hospitalization for non-operative traumaSurgery open science2025doi:10.1016/j.sopen.2025.04.008
  • Humans1

Effects

1

Length of stay

upin humans1

1 study

  1. High frailty is linked with higher length of stay in humans (non-operative trauma hospitalizations) (+5.1 days (95% CI, 4.8-5.2 days)).

    “HF patients had a prolonged LOS by 5.1 days (95 % CI, 4.8-5.2 days) and higher costs by $11,300 (95 % CI, $11,000-11,600).”

    Humansnon-operative trauma hospitalizations

    Association of frailty with clinical and financial outcomes of hospitalization for non-operative trauma

    Surgery open science

Associations

1

In-hospital mortality

upin humans1

1 study

  1. High frailty is linked with a higher risk of in-hospital mortality in humans (non-operative trauma hospitalizations) (AOR 3.3, 95% CI 2.7-4.1).

    “HF (AOR 3.3; 95 % CI, 2.7-4.1) were associated with greater odds of in-hospital mortality.”

    Humansnon-operative trauma hospitalizations

    Association of frailty with clinical and financial outcomes of hospitalization for non-operative trauma

    Surgery open science

Latest

Dec 2025: 5Jan 2026: 3Feb 2026: 6Mar 2026: 1Apr 2026: 4May 2026: 5Jun 2026: 6Jul 2026: 3Aug 2026: 8Sep 2026: 9Oct 2026: 7Nov 2026: 057 papers in 12 months
ESC Congress 2026 Abstract

Illness burden’s link to death is weaker with frailty in heart failure

High versus low illness burden was linked to 42% higher relative death risk in non-frail heart failure patients, versus 13% in frail patients.High versus low illness burden was linked to 42% higher relative death risk in non-frail heart failure patients, versus 13% in frail patients.

Cohort · 18,058 peopleHeart failure
Paper
The Canadian Journal of Neurological Sciences Le Journal Canadien des Sciences Neurologiques

Frailty links to lower thrombolysis use and male stroke deaths

Compared to low-frailty peers, highly frail stroke patients had adjusted risk ratios for thrombolysis of 0.66 in females and 0.72 in males.Compared to low-frailty peers, highly frail stroke patients had adjusted risk ratios for thrombolysis of 0.66 in females and 0.72 in males.

Cohort study of 59,346 peoplePopulations
Paper

See all 242

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