High-density coronary calcium volume

1. LDL cholesterol is associated with high-density coronary calcium volume in humans (β = 1.11, SE = 0.49 with LDL-C reduction ≥30%).

   “Among statin-treated participants, LDL-C reduction ≥30% was associated with greater progression of high-density (β = 1.11, SE = 0.49; P = 0.03)”

   Human trialAmong statin-treated participants; LDL-C reduction ≥30%coronary plaque3 yearsn = 161

   Calcium Density as a Marker of Coronary Plaque Stabilization in Primary Prevention: The CAUGHT-CAD Trial

   JACC. Cardiovascular imaging·15 Oct 2026

More on LDL cholesterol

1. Statins are associated with high-density coronary calcium volume in humans (β = 0.79, SE = 0.24).

   “and high-density (β = 0.79, SE = 0.24; P = 0.001) calcium, alongside regression of noncalcified plaque”

   Human trialPost hoc analysis of asymptomatic, statin-naive, intermediate-risk individualscoronary plaque3 years57.1% mensn = 338

   Calcium Density as a Marker of Coronary Plaque Stabilization in Primary Prevention: The CAUGHT-CAD Trial

   JACC. Cardiovascular imaging·15 Oct 2026

More on Statins