HIF1A expression

1. TP53 decreases HIF1A expression in animals.

   “TP53 activation induces cellular senescence in aging neurons and suppresses HIF-1α expression and autophagy levels within these cells.”

   AnimalsTP53 activation in spinal cord injury modelsneuron

   p53/HIF-1α regulates neuronal aging and autophagy in spinal cord ischemia/reperfusion injury

   Mechanisms of ageing and development·7 Nov 2024

More on TP53

1. Older age is associated with HIF1A expression in animals.

   “HIF-1α expression was downregulated in the spinal cord tissues of elderly animals.”

   Animalsspinal cord injury models of different age groupsspinal cord

   p53/HIF-1α regulates neuronal aging and autophagy in spinal cord ischemia/reperfusion injury

   Mechanisms of ageing and development·7 Nov 2024