Tri-HF

1. Tri-HF is associated with incident heart failure in humans (Highest versus intermediate and lowest Tri-HF risk tertiles in UKB and MGBB) (High/intermediate/low cumulative incidence: UKB 2.88%/0.56%/0.25%; MGBB 11.36%/2.96%/0.76%).

   “When stratified by Tri-HF, individuals in the highest tertile of risk showed higher cumulative incidence of HF”

   HumansHighest versus intermediate and lowest Tri-HF risk tertiles in UKB and MGBB

   Combining health records and heart tests predicts heart failure

   ESC Congress 2026 abstract·Oct 26, 2026

2. Tri-HF predicts incident heart failure in humans (UK Biobank; compared with single-component prediction models) (AUROC 0.811 (95% CI 0.789–0.834) in UKB; 0.811 (0.789–0.832) in MGBB).

   “In UKB, Tri-HF outperformed all single-component models with respect to HF discrimination”

   HumansUK Biobank; compared with single-component prediction models51.6% womensn = 51,237

   Combining health records and heart tests predicts heart failure

   ESC Congress 2026 abstract·Oct 26, 2026

More on Incident heart failure