H3K27me3 gain

1 paper studies it2 more mention it1 finding

In silico1

Associations

1

Neuronal aging

upin silico1

1 study

Neuronal aging is associated with H3K27me3 gain in silico (92% gain vs 8% loss).
“In total, 1,383 assignments, representing 92% of the interpreted set, showed gain, whereas 117, representing 8%, showed loss.”
In silicoforebrain neurons
Focal Polycomb-Mediated Repression of Neuronal Identity and Synaptic Maintenance Genes in Aging Neurons
CureusJun 30, 2026

Latest

3 papers in 12 months

CureusJul 19

CPT2 as a Convergent Node Linking Age-Associated Neuronal H3K27me3 Remodeling to Nicotinamide Mononucleotide (NMN)-Induced Expression Rescue in Metabolic Tissues

Computational studyNicotinamide mononucleotide

CureusJul 1

Focal Polycomb-Mediated Repression of Neuronal Identity and Synaptic Maintenance Genes in Aging Neurons

Computational studySynapse

FigshareJul 1

CPT2 as a Convergent Node Linking Age-Associated Neuronal H3K27me3 Remodeling to NMN-Induced Expression Rescue in Metabolic Tissues

Preprint: computational studyHistone modification and chromatin remodeling