DNMT3A mutation
Intervention1 paper2 findings
- Cells1
Outcomes
2H3K27me3
downin human cells1
1 study
H3K27me3
downin human cells1
DNMT3A mutation decreases H3K27me3 in human cells.
Cellsmacrophage
DNMT3A mutations linked to clonal hematopoiesis alter macrophage epigenetics and accelerate migration · bioRxiv · 25 Sep 2026 · Preprint
DNA methylation
downin human cells1
1 study
DNA methylation
downin human cells1
DNMT3A mutation decreases DNA methylation in human cells.
Cellsmacrophage
DNMT3A mutations linked to clonal hematopoiesis alter macrophage epigenetics and accelerate migration · bioRxiv · 25 Sep 2026 · Preprint
Latest
1CellsPreprint
DNMT3A mutations linked to clonal hematopoiesis alter macrophage epigenetics and accelerate migration
The mutations derepress Polycomb target genes at specific chromatin sites and prompt earlier macrophage recruitment to injured tissues.
bioRxiv · Lee Y et al.