Glycemic traits

1. Glycemic traits mediate type 2 diabetes in humans (19–32% of the KDMAccel burden–T2D effect; 16–24% of the PhenoAgeAccel burden–T2D effect).

   “Mediation analyses revealed that these glycemic traits on average mediated 19~32% of the KDMAccel burden-T2D effect and 16~24% of the PhenoAgeAccel burden-T2D effect.”

   HumansMediation analysis of associations between biological age acceleration burdens and incident T2Dn = 13,751

   Longitudinal insights into dynamic patterns and cumulative burdens of biological age acceleration in relation to type II diabetes mellitus, all-cause mortality and glycemic traits

   medRxiv·7 Apr 2026Preprint

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1. Glycemic traits predict DunedinPACE in humans.

   “Cross-lagged models revealed that glycemic traits (fasting plasma glucose, HbA1c, and TyG index) preceded DunedinPACE increases”

   HumansCross-lagged analysis in twins; glycemic traits comprised fasting plasma glucose, HbA1c, and TyG indexMean of 4.6 yearsn = 314

   Association between epigenetic age and type 2 diabetes mellitus or glycemic traits: A longitudinal twin study

   Aging cell·25 Apr 2024

2. DunedinPACE is associated with glycemic traits in humans.

   “In the cross-sectional analysis, positive associations were identified between DunedinPACE and glycemic traits”

   HumansCross-sectional analysis in twinsn = 1,070

   Association between epigenetic age and type 2 diabetes mellitus or glycemic traits: A longitudinal twin study

   Aging cell·25 Apr 2024

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