Pharmacological Research
IUPHAR review: From foe to friend: Repurposing glucagon to treat obesity and type 2 diabetes
ReviewObesity
Papers on GLP-1R
146 papers13 new in 30 days
Tuesday, December 30
Tuesday, December 23
bioRxiv
Tirzepatide Synergizes with Leptin on Weight Loss and Restoring Metabolic Homeostasis in Diet-induced Obesity Model
Preprint: experiments in miceTirzepatide
Wednesday, December 17
Nature
Mazdutide versus placebo in Chinese adults with type 2 diabetes
Randomized trial in 320 peopleType 2 diabetes
Friday, December 12
Molecular Metabolism
Long-acting GIPR agonist LY3537021 reduces body weight and fasting blood glucose in patients with T2D: Preclinical development and phase 1 randomized ascending dose studies
Randomized trial in 85 peopleType 2 diabetes
Friday, December 5
Ecotoxicology and Environmental Safety
Glucagon-like peptide-1 receptor (GLP-1R) agonists prevent tributyltin-induced muscle atrophy/wasting via restoring GLP-1R signaling in vitro and in mice
Experiments in miceGLP-1 receptor agonists
Thursday, November 27
Current Cardiology Reports
Epicardial Fat Inflammation and GLP-1/GIP Receptor Analogs: Are we Shifting our Perspective?
ReviewInterventions
Friday, November 21
Cell Metabolism
Body-wide multi-omic counteraction of aging with GLP-1R agonism
Experiments in miceInterventions
Tuesday, November 11
Journal of the Endocrine Society
GLP-1R Agonists for Weight Loss in Psychiatric Disorders: A Systematic Review and Meta-analysis
Meta-analysis of randomized trialsGLP-1 receptor agonists
Friday, November 7
Monday, November 3
AHA Scientific Sessions 2025 Abstract
Low-Dose Semaglutide Attenuates Coronary Artery Pathology and Improves Vascular Function Independent of Weight Loss in a Porcine Model of Cardiometabolic HFpEF
Experiments in pigsSemaglutide
Thursday, October 30
Monday, October 13
Aging and Disease
Progress in Disease-Modifying Therapies for Parkinson's Disease
ReviewParkinson's disease
Tuesday, September 30
Monday, September 8
Redox Biology
GLP-1R activation restores Gas6-driven efferocytosis in senescent foamy macrophages to promote neural repair
Experiments in miceInterventions
Tuesday, August 19
Thursday, July 24
Journal of Medicinal Chemistry
Long-Acting and Stapled GLP-1R/GIPR/GCGR Triple Agonist for the Treatment of Obesity and Atherosclerosis
Experiments in miceGLP-1 receptor agonists
Monday, July 14
International Journal of Obesity
Visual demonstration of weight loss and health risk improvement with a dual GIP and GLP-1 receptor agonist
Computational studyGLP-1 receptor agonists
Tuesday, June 24
Diabetes, Obesity & Metabolism
The effects of anti-obesity medications on bone metabolism: A critical appraisal
ReviewObesity
Friday, June 13
ADA Scientific Sessions 2025 Abstract
Titration to Maintenance Doses of GLP-1R Agonists for Overweight and Obesity Is Suboptimal for Majority of Patients—Evidence from a Real-World Claims Dataset
Cohort study of 655,419 peopleOverweight
ADA Scientific Sessions 2025 Abstract
Efficacy and Safety of BGM0504 in Chinese Patients with Obesity—A Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase 2 Trial
Randomized trial in 120 peopleObesity
ADA Scientific Sessions 2025 Abstract
Efficacy and Safety of BGM0504 in Chinese Patients with Type 2 Diabetes—A Multicenter, Randomized, Double-Blind, Placebo-Controlled and Semaglutide Positive-Controlled Phase 2 Trial
Randomized trial in 64 peopleType 2 diabetes
ADA Scientific Sessions 2025 Abstract
Tirzepatide Prevents Palmitate-Induced Apoptosis, Autophagy, and Senescence in Human Cardiac Progenitor Cells
Experiments in human cellsTirzepatide
ADA Scientific Sessions 2025 Abstract
Antibody-siRNA Conjugate Targeting Myostatin Preserves Muscle Mass during GLP-1R Agonism
Experiments in miceMuscle
ADA Scientific Sessions 2025 Abstract
Safety, Tolerability, Pharmacokinetics (PK), and Pharmacodynamics (PD) of a Dual GLP-1/GIP Receptor Agonist (HDM1005)—A Phase I, Randomized, Double-Blind, Placebo-Controlled, Single and Multiple Dose-Escalation Study
Randomized trial in 64 peopleInterventions
ADA Scientific Sessions 2025 Abstract
Safety, Tolerability, and Clinical Effects of Dapiglutide, a Once-Weekly GLP-1R/GLP-2R Agonist
Randomized trial in 54 peopleInterventions
Wednesday, June 11
Thursday, May 29
Wednesday, May 21
Nature Aging
Activation of AMPK by GLP-1R agonists mitigates Alzheimer-related phenotypes in transgenic mice
Experiments in miceGLP-1 receptor agonists