Papers on GLP-1R

146 papers13 new in 30 days

Tuesday, October 27

Journal of Clinical MedicineOct 27

Effectiveness of the Dual GLP-1R/GCGR Agonist Mazdutide in GSD IXc: A Case Report

Pedigree chart of patient and sequencing results of the PHKG2 mutations.

Case reportInterventions

Monday, October 26

ESC Congress 2026 AbstractOct 26

Triple GLP-1R/GIP-R/GCGR activation synergistically suppresses macrophage-driven oxidative stress and activation in human epicardial adipose tissue from patients with a history of atrial fibrillation

Study of 20 peopleAtrial fibrillation

ESC Congress 2026 AbstractOct 26

Combined SGLT2 inhibition and GLP-1 receptor agonism synergistically reduce rejection-associated oxidative stress in cardiac allografts of heart transplant recipients

Study of 100 peopleGLP-1 and incretin signaling

ESC Congress 2026 AbstractOct 26

Epicardial adipose tissue Glucagon-like peptide-1 receptor upregulation in human atrial fibrillation might be functionally offset by accompanying Phosphodiesterase-4 upregulation

Cross-sectional study in peopleMechanisms

Saturday, October 24

bioRxivOct 24

Central Glucagon-Like Peptide-1 Agonism Ameliorates Colonic Inflammation in a Murine Model of Inflammatory Bowel Disease

Preprint: experiments in miceInflammatory bowel disease

Sunday, October 18

Research Results in PharmacologyOct 18

Semaglutide reduces hypothalamic glial cell damage in a streptozocin-induced model of Alzheimer's disease

Experiments in animalsSemaglutide

Monday, October 12

The European Respiratory JournalOct 12

GLP-1-based therapies in lung diseases

ReviewLung

Friday, October 9

European Journal of PharmacologyOct 9

GLP-1 Receptor Biology and the Therapeutic Role of Incretin-Based Agonists in Metabolic Diseases

ReviewGLP-1 receptor agonists

Wednesday, October 7

Alzheimer's & DementiaOct 7

Brain receptor gene activity linked to lower Alzheimer’s risk

An analysis of inherited genetic differences linked a hormone receptor’s gene activity to lower disease risk, with results pointing mainly to the brain’s outer layer.An analysis of inherited genetic differences linked a hormone receptor’s gene activity to lower disease risk, with results pointing mainly to the brain’s outer layer.

The study design. AD, Alzheimer's disease; BMI, body mass index; cis‐eQTL, cis‐expression quantitative trait locus; cis‐MVMR, cis multivariable Mendelian randomization; CSF, cerebrospinal fluid;…

Mendelian randomization in peopleMechanisms

Monday, October 5

Pharmacology Research & PerspectivesOct 5

Glucagon-Like Peptide-1 Agonists and Blood Pressure Regulation: Molecular Mechanisms and Cardiovascular Implications

Overview of GLP‐1 receptor intracellular signaling pathways relevant to cardiovascular and blood pressure regulation.

ReviewGLP-1 receptor agonists

Thursday, October 1

Neurology GeneticsOct 1

GLP-1 receptor agonists link to lower stroke and Alzheimer risk

A cross-ancestry Mendelian randomization study of up to 1,812,017 individuals linked genetically proxied GLP-1 receptor agonist exposure to reduced risk of stroke and…A cross-ancestry Mendelian randomization study of up to 1,812,017 individuals linked genetically proxied GLP-1 receptor agonist exposure to reduced risk of stroke and Alzheimer disease.

Summary of Analysis Plan.

Mendelian randomization in peopleGLP-1 receptor agonists

Tuesday, September 29

Diabetes TherapySep 29

New Amylin-Based Agonists for the Treatment of Obesity and Type 2 Diabetes Mellitus

Monday, September 28

International Journal of Molecular SciencesSep 28

Skeletal Muscle Effects of GLP 1 Receptor Agonists: Molecular Mechanisms and Comparative Insights on Semaglutide and Tirzepatide, a Narrative Review

Signaling mediated by GLP-1 receptors (GLP-1R) and GIP receptors (GIPR) in β, δ, and α cells of the pancreatic islet.

ReviewGLP-1 receptor agonists

Saturday, September 26

BiomedicinesSep 26

Genetic Assessment of Oesophageal Safety of GLP-1 and GIP Receptor Perturbation: A Drug-Target Mendelian Randomisation Study

Conceptual model and interpretation framework.

Mendelian randomization in 31,684 peopleBarrett's esophagus

Wednesday, September 23

Biochemical PharmacologySep 23

GLP-1 receptor agonists and podocyte senescence in diabetic kidney disease: structural pharmacology, mechanistic evidence, and multi-receptor agonism

ReviewGLP-1 receptor agonists

Friday, September 18

Diabetes, Obesity & MetabolismSep 18

Effectiveness, Safety and Pharmacokinetics of BGM0504, a Dual GLP-1/GIP Receptor Agonist, in Chinese Adults With Overweight or Obesity Without Diabetes: A Phase 2 Multicentre, Randomized, Double-Blind, Placebo-Controlled Trial

Randomized trial in 120 peopleOverweight

Friday, September 11

The International Journal of Lower Extremity WoundsSep 11

Assessing the Association Between GLP-1 Receptor Agonists and Diabetic Foot Complications Using Real-World Pharmacovigilance Database and Mendelian Randomization

Mendelian randomization in peopleGLP-1 receptor agonists

Wednesday, September 9

Preprints.orgSep 9

Semaglutide and Papillary Thyroid Carcinoma: Current Evidence on Risk, Progression, and Mechanisms

Preprint: reviewSemaglutide

Thursday, September 3

NatureSep 3

Late-life semaglutide treatment slows ageing and extends lifespan in female mice

GLP-1R activation late in life extends lifespan and improves physiological function.

Experiments in miceSemaglutide

Friday, August 21

Diabetes CareAug 21

Cardiometabolic Effects of Dual GLP-1 and Glucagon Receptor Agonists: A Systematic Review and Meta-analysis of Randomized Controlled Trials

Meta-analysis of randomized trialsCardiometabolic disease

Thursday, August 20

Frontiers in NutritionAug 20

Citrus Changshan Huyou extracts as natural GLP-1R agonists attenuate atherosclerosis via the GLP-1R/PKA/CREB pathway: a functional food perspective

Experiments in miceAtherosclerosis

Saturday, August 15

CureusAug 15

Maximizing Metabolic Synergy: A Review of Dual Incretin Therapy as a Step-Up Strategy Following Glucagon-Like Peptide-1 (GLP-1) Monotherapy Failure or Optimization

Proposed clinical phenotyping framework for incretin escalation.

Systematic review of randomized trialsInterventions

Thursday, August 13

Zhonghua Xin Xue Guan Bing Za ZhiAug 13

Gastrointestinal metabolic surgery improves salt-sensitive hypertension via GLP-1-mediated inhibition of the RAS/NHE3 axis

Experiments in 48 ratsHypertension

Monday, August 3

Problemy EndokrinologiiAug 3

Semaglutide-Induced Sarcopenia via GLP-1R-mTOR-Satellite Cells Axis and Muscle-Glucose Feedback Loop Potentially Leading to Refractory Hyperglycemia in Type 2 Diabetes: A Case-Driven Hypothesis

Case reportSemaglutide

Sunday, August 2

European Journal of EndocrinologyAug 2

Safety of glucagon-like peptide-1 receptor agonists in neuroendocrine neoplasms

ReviewGLP-1 receptor agonists

Thursday, July 30

American Journal of Physiology Endocrinology and MetabolismJul 30

PYY₃₋₃₆ potentiates semaglutide-mediated mitochondrial modulation in MASLD

Experiments in ratsSemaglutide

Thursday, July 23

bioRxivJul 23

GLP-1 and GIP receptor agonism does not directly drive skeletal muscle atrophy or impair myogenesis in primary human myotubes

Preprint: experiments in human cellsMuscle

Thursday, July 16

Journal of Translational MedicineJul 16

Glucagon receptor blockade protects spermatogenesis by enhancing PFKFB3-mediated lactate production in Sertoli cells

Experiments in miceInterventions

Wednesday, July 8

Cell Reports MedicineJul 8

Preventative semaglutide and tirzepatide treatment does not alter disease progression in the 5xFAD mouse model of Alzheimer's disease

Experiments in miceTirzepatide

Friday, June 26

GenesJun 26

Molecular Basis of Synergistic Causal Effect of Dual GLP-1R and GIPR Agonists for Risk Reduction in Diabetic Retinopathy, Alzheimer Disease, and Coronary Artery Disease in Diabetic Patients

Study in peopleInterventions