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FRAIL

Biomarker

20 papers study it10,214 more mention it11 findings

194 new papers in 30 daysSee all 10,234

  • Human trial1
  • Humans16

Associations

10

In-hospital mortality

upin humans2OR 9.29

2 studies

  1. FRAIL predicts in-hospital mortality in humans (OR 9.29, 95% CI 1.09–79.20; 6.7% versus 1.0%).

    “FRAIL-frail was superior for in-hospital mortality [6.7% vs 1.0%, P = .031, odds ratio (OR) 9.29, 95% confidence interval (CI) 1.09-79.20, P < .042]”

    HumansHospitalized for an acute medical illnessDuring hospitalization

    Concurrent and Predictive Validity of FRAIL-NH in Hospitalized Older Persons: An Exploratory Study

    Journal of the American Medical Directors Association

  2. FRAIL is associated with in-hospital mortality in humans (6.7% vs 1.0%).

    “Only FRAIL was associated with higher in-hospital mortality (6.7% vs 1.0%, P = .031).”

    Humansacutely ill hospitalized older adults; frail versus nonfrailduring hospitalization69.5% femalesn = 210

    Frailty in Hospitalized Older Adults: Comparing Different Frailty Measures in Predicting Short- and Long-term Patient Outcomes

    Journal of the American Medical Directors Association

Postoperative muscle weakness

upin humans1HR 1.83

1 study

  1. FRAIL raises the risk of postoperative muscle weakness in humans (HR = 1.83, 95%CI: 1.51-2.15).

    “frail (HR = 1.83, 95%CI: 1.51-2.15) individuals had significantly higher muscle weakness risks versus robust”

    Humansversus robustn = 405

    Dynamic frailty trajectories identify thymoma patients at high risk of postoperative muscle weakness

    International journal of surgery (London, England)

Frailty

upin humans1

1 study

  1. FRAIL predicts frailty in humans (Sensitivity 0.75 (95% CI 0.56–0.88); specificity 0.81 (95% CI 0.71–0.88); AUC 0.88 (95% CI 0.85–0.91)).

    “The pooled sensitivity, specificity and AUC of FRAIL was 0.75 (95% Confidence Interval 0.56–0.88), 0.81 (95% CI: 0.71–0.88) and 0.88”

    ReviewFried phenotype scale as the reference standard

    Comparison of Diagnostic Accuracies of Frailty Assessment Tools for Frailty in Older People

    Research SquarePreprint

Disability

upin humans1OR 5.55

1 study

  1. FRAIL predicts disability in humans (Adjusted OR 5.55).

    “FRAIL conferred the greatest risk of 4-year disability, followed by FI and TFI (aOR 5.55, 3.50, and 1.91, respectively).”

    HumansCommunity-dwelling older adults in Shanghai4 years46.6% malesn = 5,402

    Frailty and risk of adverse outcomes among community-dwelling older adults in China: a comparison of four different frailty scales

    Frontiers in public health

Length of stay

upin humans1

1 study

  1. FRAIL predicts length of stay in humans (10 versus 8 days; P = .043).

    “FRAIL-frail was superior for in-hospital mortality [6.7% vs 1.0%, P = .031, odds ratio (OR) 9.29, 95% confidence interval (CI) 1.09-79.20, P < .042] and LOS (10 vs 8 days, P = .043)”

    HumansHospitalized for an acute medical illnessDuring hospitalization

    Concurrent and Predictive Validity of FRAIL-NH in Hospitalized Older Persons: An Exploratory Study

    Journal of the American Medical Directors Association

Functional decline

upin humans1

1 study

  1. FRAIL predicts functional decline in humans (AUC 0.63).

    “FRAIL and FI had similar predictive value for functional decline (AUC 0.63,0.65).”

    Humans58.5% femalesn = 188

    Comparison of Three Frailty Scales for Prediction of Adverse Outcomes among Older Adults: A Prospective Cohort Study

    The journal of nutrition, health & aging

Unplanned hospital visits

upin humans1

1 study

  1. FRAIL predicts unplanned hospital visits in humans (AUC 0.64).

    “The three scales had similar predictive value for unplanned hospital visits (area under ROC, AUC 0.63, 0.64 and 0.69).”

    Humans58.5% femalesn = 188

    Comparison of Three Frailty Scales for Prediction of Adverse Outcomes among Older Adults: A Prospective Cohort Study

    The journal of nutrition, health & aging

Frailty classification by Frailty Index

upin humans1

1 study

  1. FRAIL predicts frailty classification by Frailty Index in humans (AUC 0.71 (95% CI 0.55 to 0.86)).

    “and 0.71 (95%CI 0.55 to 0.86, p=0.008) against FI.”

    HumansFRAIL cut-off ≥1n = 517

    Frailty Assessment in Community-Dwelling Older Adults: A Comparison of 3 Diagnostic Instruments

    The journal of nutrition, health & aging

Frailty classification by Fried Phenotype

upin humans1

1 study

  1. FRAIL predicts frailty classification by Fried Phenotype in humans (AUC 0.70 (95% CI 0.55 to 0.86)).

    “A lower FRAIL cut-off ≥1 yielded significantly improved AUC of 0.70 (95%CI 0.55 to 0.86, p=0.009) against Fried”

    HumansFRAIL cut-off ≥1n = 517

    Frailty Assessment in Community-Dwelling Older Adults: A Comparison of 3 Diagnostic Instruments

    The journal of nutrition, health & aging

Length of hospitalization

upin humans1

1 study

  1. FRAIL is associated with length of hospitalization in humans (10 [6.0-17.5] vs 8 [5.0-14.0] days).

    “FRAIL and CFS were significantly associated with increased length of hospitalization”

    Humansacutely ill hospitalized older adults; frail versus nonfrail69.5% femalesn = 210

    Frailty in Hospitalized Older Adults: Comparing Different Frailty Measures in Predicting Short- and Long-term Patient Outcomes

    Journal of the American Medical Directors Association

Funding

6 grants since 2025

Natural Science Foundation of Hunan ProvinceJapan Society for the Promotion of ScienceJP¥23.4m

Latest

European Journal of Haematology

Frailty linked to lower survival after donor stem cell transplants

Two-year survival was 78.9% in fit adults, 66.0% in those classified as prefrail and 51.7% in those classified as frail.Two-year survival was 78.9% in fit adults, 66.0% in those classified as prefrail and 51.7% in those classified as frail.

Cohort · 992 peopleBiomarkers
Paper
medRxiv

Electronic frailty index linked to death risk in older adults

One-year mortality was 18.7% in severely frail patients compared with 0.9% in fit individuals in an Israeli health maintenance organization.One-year mortality was 18.7% in severely frail patients compared with 0.9% in fit individuals in an Israeli health maintenance organization.

Preprint: cohort · 641,748 peopleBiomarkers
Paper
The Journal of International Medical Research

Model estimates four-year frailty risk in adults with arthritis

The model scored 0.764 in distinguishing who developed frailty in internal validation, versus 0.747 in a separate Korean cohort.The model scored 0.764 in distinguishing who developed frailty in internal validation, versus 0.747 in a separate Korean cohort.

Cohort · 2,126 peopleArthritis
Paper

See all 10,234

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