Florbetapir PET PC2+WM SUVR

1. Florbetapir PET PC2+WM SUVR predicts neuritic plaque positivity in humans (AUC 0.82 (95% CI 0.76–0.89)).

   “0.82 (95% CI 0.76–0.89) for neuritic plaque, with an optimal cutoff of 0.77 for both outcomes.”

   Humansbrainn = 165

   Amyloid quantification in the oldest-old: selecting regions for optimizing correspondence between postmortem pathology and amyloid PET

   Acta neuropathologica communications·1 Dec 2025

More on Neuritic plaque positivity

1. Florbetapir PET PC2+WM SUVR predicts amyloid-beta positivity in humans (AUC 0.84 (95% CI 0.78–0.90)).

   “The best performing SUVR was the PC2+WM, yielding an area under the curve (AUC) of 0.84 (95% CI 0.78–0.90) for amyloid beta”

   Humansbrainn = 165

   Amyloid quantification in the oldest-old: selecting regions for optimizing correspondence between postmortem pathology and amyloid PET

   Acta neuropathologica communications·1 Dec 2025

More on Amyloid-beta positivity