International Journal of Ophthalmology
SIRT1 inhibits apoptosis of human lens epithelial cells through suppressing endoplasmic reticulum stress in vitro and in vivo
Experiments in ratsER unfolded protein response
Papers on Factor 4
140 papers6 new in 30 days
Tuesday, June 25
Monday, May 27
Sunday, April 28
Cell Reports
Thbs1 regulates skeletal muscle mass in a TGFβ-Smad2/3-ATF4-dependent manner
Experiments in miceSMAD2
Saturday, April 6
Monday, April 1
Sunday, March 17
bioRxiv
ATF4 orchestrates IL-1α-induced senescence in adult neural stem cells
Preprint: experiments in ratsCellular senescence
Wednesday, March 13
Aging Cell
Dermal stiffness governs the topography of the epidermis and the underlying basement membrane in young and old human skin
Cross-sectional study in peoplePlasma membrane
Tuesday, January 9
Cardiovascular Research
Endothelium-specific SIRT7 targeting ameliorates pulmonary hypertension through Krüpple-like factor 4 deacetylation
Experiments in micePulmonary hypertension
Friday, November 10
Trends in Molecular Medicine
Youth-associated platelet-derived chemokine reverses brain aging through neuroimmune mechanisms
Experiments in miceInterventions
Thursday, October 12
Thursday, September 28
Advanced Science
The Critical Role of The Piezo1/β-catenin/ATF4 Axis on The Stemness of Gli1⁺ BMSCs During Simulated Microgravity-Induced Bone Loss
Experiments in animalsMechanisms
Wednesday, August 23
bioRxiv
Senescence suppresses the integrated stress response and activates a stress-enhanced secretory phenotype
Preprint: experiments in human cellsIntegrated stress response
Thursday, August 17
Nature
Platelet factors attenuate inflammation and rescue cognition in ageing
Experiments in miceInterventions
Nature Aging
Platelet factors are induced by longevity factor klotho and enhance cognition in young and aging mice
Experiments in miceInterventions
Nature Communications
Platelet-derived exerkine CXCL4/platelet factor 4 rejuvenates hippocampal neurogenesis and restores cognitive function in aged mice
Experiments in miceInterventions
Friday, August 11
Animal Models and Experimental Medicine
Platelet factor 4 induces bone loss by inhibiting the integrin α5-FAK-ERK pathway
Experiments in miceIntegrin signaling
Tuesday, July 11
Saturday, April 22
Sunday, April 16
European Journal of Epidemiology
Adherence to a healthy lifestyle and brain structural imaging markers
Cohort study of 19,822 peoplePopulations
Sunday, February 26
Biomedicines
The Relationship between Elevated Homocysteine and Metabolic Syndrome in a Community-Dwelling Middle-Aged and Elderly Population in Taiwan
Cross-sectional study of 398 peopleHomocysteine
Sunday, January 15
Thursday, November 24
Preprints.org
Does Losing Weight Lower the Risk of Cancer: A Systematic Review and Meta-analysis
Preprint: meta-analysisCancer
Tuesday, November 15
Saturday, September 24
Cellular and Molecular Life Sciences
Melatonin relieves hepatic lipid dysmetabolism caused by aging via modifying the secondary bile acid pattern of gut microbes
Experiments in animalsMelatonin
Friday, August 19
Cellular Signalling
FOXO1 differentially regulates bone formation in young and aged mice
Experiments in miceFOXO1
Thursday, July 28
Tuesday, July 26
Nature Metabolism
Sensing of the non-essential amino acid tyrosine governs the response to protein restriction in Drosophila
Experiments in fliesIntegrated stress response
Thursday, May 5
European Journal of Clinical Investigation
KLF4 prevented angiotensin II-induced smooth muscle cell senescence by enhancing autophagic activity
Experiments in miceAutophagy
Friday, April 29
International Journal of Environmental Research and Public Health
Adaptation and Validation of the Individual Lifestyle Profile Scale of Portuguese Older Adults Living at Home
Cross-sectional study of 300 peopleBiomarkers