Trends in Molecular Medicine · Nov 7, 2023

Youth-associated platelet-derived chemokine reverses brain aging through neuroimmune mechanisms

By Hemmer BM, Philippi SM, Castellano JM

Age-related loss of brain function has been seen as inevitable, yet recent work leveraging the systemic environment challenges this notion. Schroer et al. demonstrate that youth-associated platelet factor 4 (PF4) partially restores brain function in aged mice while reducing peripheral immune dysfunction, supporting periphery-based approaches to treat age-associated brain disorders.

doi.org/10.1016/j.molmed.2023.10.007Open access, accepted manuscriptPubMed 37945435Interventions