Expression of X-inactivation escape genes

1. Loss of chromosome Y is associated with expression of X-inactivation escape genes in humans.

   “we observed upregulation of genes known to escape X-inactivation, including male-biased cancer-related genes KDM6A , DDX3X , KDM5C, and ZRSR2 .”

   Humansimmune cellmales

   Loss of chromosome Y shapes the immune cell fate with aging in men

   medRxiv·2 Jun 2025Preprint

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