Profibrotic transcriptional signature

1. Loss of chromosome Y is associated with profibrotic transcriptional signature in humans.

   “LOY is associated with a profibrotic signature in classical monocytes”

   Humansclassical monocytesmalesn = 416

   Loss of Chromosome Y Associates With Altered Immune Cell Trajectories and X-Inactivation Features

   Aging cell·1 May 2026

2. Loss of chromosome Y is associated with profibrotic transcriptional signature in humans.

   “These monocytes exhibit a profibrotic signature marked by downregulation of IL1B and MYC-regulated genes”

   Humansclassical monocytemales

   Loss of chromosome Y shapes the immune cell fate with aging in men

   medRxiv·2 Jun 2025Preprint

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