Expression of genes typically downregulated in neurodegenerative microglia

1. Surgery increases expression of genes typically downregulated in neurodegenerative microglia in mice.

   “surgery upregulates genes typically downregulated in the context of neurodegenerative diseases.”

   Animalscomparison with published MGnD/DAM phenotypeabdominal laparotomymicroglia

   Microglia in the aged brain develop a hypoactive molecular phenotype after surgery

   Journal of neuroinflammation·18 Dec 2024

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