Excitation-inhibition ratio

1. APOE increases excitation-inhibition ratio in humans (p = 0.018).

   “female APOE‐ε4 carriers demonstrate an elevated hyperexcitable EIR trajectory ( p = 0.018).”

   Humanslongitudinal trajectoryfemales

   Longitudinal Sex Differences in Excitation–Inhibition Balance in Alzheimer's Disease Risk: A Multimodal Neuroimaging Study

   AAIC 2025 abstract·9 Jan 2026

2. APOE increases excitation-inhibition ratio in humans (p = 0.018).

   “female APOE‐ε4 carriers demonstrate an elevated hyperexcitable EIR trajectory ( p = 0.018).”

   Humansfemales

   Longitudinal Sex Differences in Excitation–Inhibition Balance in Alzheimer’s Disease Risk: A Multimodal Neuroimaging Study

   AAIC 2025 abstract·23 Dec 2025

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