Longitudinal Sex Differences in Excitation–Inhibition Balance in Alzheimer’s Disease Risk: A Multimodal Neuroimaging Study

Abstract

Background: Excessive neural hyperexcitation has been implicated in early cognitive decline and progression to Alzheimer’s disease (AD). Restoring the balance between excitation and inhibition (E/I) with interventions like levetiracetam may offer clinical benefits, particularly for those at heightened risk.