2 papers study it7 more mention it2 findings
Pyridoxamine
upin mice1
Pyridoxamine increases ESR1 expression in mice.
“Glomerular ERα mRNA expression was upregulated in mice treated with both Pyr and E2 replacement”
Animalsovariectomized; estradiol replacementkidney glomerulusfemales
PloS one
Advanced glycation end products
downin mouse cells1
Advanced glycation end products decrease ESR1 expression in mouse cells.
“we treated mesangial cells from young female mice with AGE-BSA and found similar downregulation of ERα, SIRT1, and AGER1 expression.”
CellsAGE-BSA treatmentmesangial cellfemales
PloS one
Lab experiments in bone marrow cells from patients with postmenopausal osteoporosis also found reduced senescence, a state in which cells stop dividing.Lab experiments in bone marrow cells from patients with postmenopausal osteoporosis also found reduced senescence, a state in which cells stop dividing.