Epicardial adipose tissue thickness

1. Ketogenic diet decreases epicardial adipose tissue thickness in humans (from 7.00 ± 0.82 to 4.76 ± 0.40 (p < 0.01)).

   “and EAT (from 7.00 ± 0.82 to 4.76 ± 0.40; p < 0.01) were observed in the VLCKD compared to baseline values”

   Human trialin post-menopausal women with hypertension and obesity6 monthsfemalesn = 43

   Very low-calorie ketogenic diet reduces left ventricular mass and epicardial adipose tissue in post-menopausal women with essential hypertension and obesity: A single-center, prospective, open-label, clinical study

   Nutrition, metabolism, and cardiovascular diseases : NMCD·13 Sep 2025

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1. Dapagliflozin decreases epicardial adipose tissue thickness in humans (-25.37%).

   “EAT thickness decreased significantly (25.37%) in all patients over 4 yrs (p= 0.03).”

   Human trialin T2DM patients with stable CAD4 yrs

   The Significant Reduction in Epicardial Adipose Tissue Thickness after Dapagliflozin Treatment Is Preserved and Even Increased after Four Years—The DAPAHEART Four-Year Follow-up Study

   ADA Scientific Sessions 2025 abstract·13 Jun 2025

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1. Epicardial adipose tissue thickness is associated with coronary artery calcium score in humans (r = 0.375).

   “Although both PCAT (r = 0.461, p < 0.001) and EAT thickness (r = 0.375, p < 0.001) correlated with CACS,”

   Humansepicardial adipose tissuen = 1,032

   Association of pericoronary and epicardial adipose tissue thickness with coronary artery calcium score using cardiac computed tomography

   Irish journal of medical science·12 Oct 2026

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