Energy metabolism protein ubiquitination

Advanced maternal age is associated with energy metabolism protein ubiquitination in humans.

“the ubiquitination levels of proteins associated with the "TCA cycle" pathway are upregulated, whereas those related to "glycolysis" and the "PPP" are downregulated.”

Humansovarian agingluteinized granulosa cellfemales

Ubiquitinated proteomics reveals potential epigenetic-energy metabolism mechanisms in senescent ovarian granulosa cells of advanced maternal age

Journal of assisted reproduction and genetics·29 Jun 2026