EMAP-II
1 paper4 findings
- Humans1
Interventions
1Passive heat exposure
upin humans1
1 study
Passive heat exposure
upin humans1
Passive heat exposure increases EMAP-II in humans.
“Young adults exhibited significant increases in EMAP-II, whereas older adults without HTN or T2D showed a blunted response.”
Human trialyoung adultsserum40°C, 9% relative humidity9 hn = 19
American journal of physiology. Regulatory, integrative and comparative physiology9 Jan 2026
Associations
3Type 2 diabetes
upin humans1
1 study
Type 2 diabetes
upin humans1
Type 2 diabetes is associated with EMAP-II in humans (5.6 pg/mL higher (95% CI 4.2–7.0); P < 0.001).
“and T2D [5.6 (4.2, 7.0) pg/mL; P < 0.001] compared with older adults without HTN or T2D.”
Humansbaseline; compared with older adults without hypertension or type 2 diabetesserum
American journal of physiology. Regulatory, integrative and comparative physiology9 Jan 2026
Hypertension
upin humans1
1 study
Hypertension
upin humans1
Hypertension is associated with EMAP-II in humans (4.7 pg/mL higher (95% CI 3.3–6.1); P < 0.001).
“EMAP-II concentrations were significantly elevated at baseline in older adults with HTN [4.7 (3.3, 6.1) pg/mL; P < 0.001]”
Humansbaseline; compared with older adults without hypertension or type 2 diabetesserum
American journal of physiology. Regulatory, integrative and comparative physiology9 Jan 2026
Younger age
upin humans1
1 study
Younger age
upin humans1
Younger age is associated with EMAP-II in humans (1.9 pg/mL higher (95% CI 0.8–3.0); P < 0.014).
“EMAP-II concentrations were significantly higher at end-exposure in young adults compared with older adults without HTN or T2D”
Human trialyoung adults compared with older adults without hypertension or type 2 diabetes, at end-exposureserum40°C, 9% relative humidity9 h
American journal of physiology. Regulatory, integrative and comparative physiology9 Jan 2026