DunedinPACE acceleration

1. DunedinPACE acceleration is associated with physical function in humans.

   “At baseline, higher DunedinPACE acceleration was associated with greater adiposity and poorer physical function.”

   HumansBaseline assessment in adults with stage II-III colon cancer

   Epigenetic aging during adjuvant chemotherapy for colon cancer and modification by a resistance training intervention

   Journal of the National Cancer Institute·3 Aug 2026

1. DunedinPACE acceleration is associated with adiposity in humans.

   “At baseline, higher DunedinPACE acceleration was associated with greater adiposity and poorer physical function.”

   HumansBaseline assessment in adults with stage II-III colon cancer

   Epigenetic aging during adjuvant chemotherapy for colon cancer and modification by a resistance training intervention

   Journal of the National Cancer Institute·3 Aug 2026

1. Adjuvant chemotherapy is associated with DunedinPACE acceleration in humans (0.70 SD per 6 months (95% CI 0.41–0.98)).

   “DunedinPACE acceleration showed the largest increase during treatment (0.70 SD per 6 months, 95% CI: 0.41, 0.98)”

   Human trialLongitudinal change during adjuvant chemotherapy for stage II-III colon cancerblood

   Epigenetic aging during adjuvant chemotherapy for colon cancer and modification by a resistance training intervention

   Journal of the National Cancer Institute·3 Aug 2026

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