Digital sleep biomarker

Digital sleep biomarker predicts braak3+ tau pathology in humans (AUROC=0.75).

“A final trained model identified asymptomatic individuals with Braak3+ tau pathology with area under the receiver operating characteristic curve (AUROC)=0.75; comparable to plasma pTau217”

Humansasymptomaticbrain239.8±108.7 nights/participant49% femalesn = 161

Remote detection of Alzheimer's disease pathology using a digital sleep and circadian biomarker: an InSleep46 study

AAIC 2025 abstract·9 Jan 2026

Digital sleep biomarker predicts braak3+ tau pathology in humans (AUROC=0.75).

“A final trained model identified asymptomatic individuals with Braak3+ tau pathology with area under the receiver operating characteristic curve (AUROC)=0.75”

Humansn = 161

Remote detection of Alzheimer's disease pathology using a digital sleep and circadian biomarker: an InSleep46 study

AAIC 2025 abstract·23 Dec 2025