Digital clock drawing test

1. Depressive symptoms impair digital clock drawing test in humans (beta=-8.78, 95% CI [-14.66, -2.90], p = 0.004).

   “those with greater PiB burden at baseline and higher GDS slopes showed declining DCT performance over time (beta=‐8.78,95%CI[‐14.66,‐2.90], p = 0.004)”

   Humanshigher baseline cortical amyloid burdencortexmean years follow‐up=5.7±0.958% femalesn = 90

   Impact of baseline amyloid and depressive symptom trajectory on longitudinal digital clock scores in community dwelling older adults

   AAIC 2025 abstract·25 Dec 2025

1. Digital clock drawing test lowers the risk of dementia in humans (HR=0.78, p = .02).

   “overall dCDT (MCI: HR=0.88, p = .03; all‐cause dementia: HR=0.78, p = .02)”

   Humansn = 1,601

   Associations of Digital Clock Drawing Test with Subjective Cognitive Decline and Risk for Mild Cognitive Impairment and Dementia

   AAIC 2025 abstract·25 Dec 2025

More on Dementia

1. Digital clock drawing test lowers the risk of mild cognitive impairment in humans (HR=0.88, p = .03).

   “overall dCDT (MCI: HR=0.88, p = .03; all‐cause dementia: HR=0.78, p = .02)”

   Humansn = 1,601

   Associations of Digital Clock Drawing Test with Subjective Cognitive Decline and Risk for Mild Cognitive Impairment and Dementia

   AAIC 2025 abstract·25 Dec 2025

More on Mild cognitive impairment

1. Digital clock drawing test lowers the risk of subjective cognitive decline in humans (OR=0.86, p = .007).

   “Better performance on dCDT—but not traditional NP tests—was associated with reduced odds of SCD: overall (OR=0.86, p = .007)”

   Humansn = 1,601

   Associations of Digital Clock Drawing Test with Subjective Cognitive Decline and Risk for Mild Cognitive Impairment and Dementia

   AAIC 2025 abstract·25 Dec 2025

More on Subjective cognitive decline