Digital Clock and Recall

1. Alzheimer's disease decreases Digital Clock and Recall in humans (median 0 vs 4, Z=-5.46, p < 0.0001).

   “The AD group had significantly lower DCR scores (median = 0, 1.68) compared to unimpaired individuals (median=4, SD=1.41; Z=‐5.46, p <0.0001).”

   Humansn = 465

   The Digital Clock and Recall and Its Relationships with Standard Assessment of Alzheimer’s Diagnosis: Insights from the UK SBS‐IONA Clinical Study

   AAIC 2025 abstract·23 Dec 2025

More on Alzheimer's disease

1. Digital Clock and Recall is associated with cognitive function in humans (TICS Z=2.45, p <0.05; ACE-R Z=2.91, p <0.005).

   “We found concordance of DCR with NIHTB‐CB (Q4: Z=‐3.17, p <0.01; Q5: Z=‐2.04, p <0.05), TICS (Z=2.45, p <0.05), and ACE‐R (Z=2.91, p <0.005).”

   Humansn = 465

   The Digital Clock and Recall and Its Relationships with Standard Assessment of Alzheimer’s Diagnosis: Insights from the UK SBS‐IONA Clinical Study

   AAIC 2025 abstract·23 Dec 2025

1. Digital Clock and Recall predicts Alzheimer's disease in humans (Z=-2.28, p < 0.05).

   “Finally, the only significant predictors of AD were DCR (Z=‐2.28, p <0.05), age (Z=0.27, p <0.01), and NIHTB‐CB (Q1: Z=3.02; Q3: Z=‐2.54; Q4: Z=‐1.96; all p < 0.05).”

   Humansn = 465

   The Digital Clock and Recall and Its Relationships with Standard Assessment of Alzheimer’s Diagnosis: Insights from the UK SBS‐IONA Clinical Study

   AAIC 2025 abstract·23 Dec 2025

More on Alzheimer's disease

1. Digital Clock and Recall predicts cognitive impairment in humans (AUC=0.85).

   “Cognitive‐impairment identification by the DCR (AUC=0.85) was superior to Aβ42/40, pTau‐181, and pTau‐217 (AUCs=0.63, 0.66, 0.72) and non‐inferior to RAVLT and MMSE (AUCs=0.89, 0.82).”

   HumansBio-Hermes-001 cohortn = 930

   Streamlining Recruitment for AD Clinical Trials: Concurrent Detection of Cognitive Impairment and Amyloid‐Beta PET Status with a Machine Learning‐Enabled Digital Cognitive Assessment

   AAIC 2025 abstract·23 Dec 2025

More on Cognitive impairment