Diffusion tensor imaging along the perivascular space index

1. Older age decreases diffusion tensor imaging along the perivascular space index in humans (p<0.001).

   “reduced DTI-ALPS (p<0.001) compared to younger adults”

   Humansbrainn = 30

   Multimodal MRI Insights into Glymphatic Clearance and Blood-Brain Barrier Integrity in Healthy Aging

   bioRxiv : the preprint server for biology·1 Dec 2025Preprint

1. Water exchange rate across the blood-brain barrier is associated with diffusion tensor imaging along the perivascular space index in humans (β=0.402×10−2, p=0.022).

   “Kw associated with both DTI-ALPS (β=0.402×10 −2 , p=0.022)”

   Humansbrainn = 30

   Multimodal MRI Insights into Glymphatic Clearance and Blood-Brain Barrier Integrity in Healthy Aging

   bioRxiv : the preprint server for biology·1 Dec 2025Preprint

More on Water exchange rate across the blood-brain barrier