Dementia PRS

2 papers3 findings

Humans2

Effects

1

Cognitive function

downin humans1

1 study

Dementia PRS impairs cognitive function in humans (p < 0.05).
Humans8.4 yearsn = 4,336
The role of polygenic risk in Alzheimer's disease prediction for African Americans
Alzheimer's & dementia : the journal of the Alzheimer's Association1 Aug 2026

Associations

1

Alzheimer's disease

upin humans1HR 1.36–1.53

1 study

Dementia PRS predicts Alzheimer's disease in humans (HR = 1.53, 95% CI: 1.03-2.27).
Humansin African Americans after APOE ε4 adjustment8.4 yearsn = 4,336
The role of polygenic risk in Alzheimer's disease prediction for African Americans
Alzheimer's & dementia : the journal of the Alzheimer's Association1 Aug 2026
Dementia PRS raises the risk of Alzheimer's disease in humans (HR = 1.36, 95% CI: 1.04-1.78).
Humansin African Americans8.4 yearsn = 4,336
The role of polygenic risk in Alzheimer's disease prediction for African Americans
Alzheimer's & dementia : the journal of the Alzheimer's Association1 Aug 2026

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