Cyp1a1 and Cyp1a2 mRNA

Older age is associated with Cyp1a1 and Cyp1a2 mRNA in mice (approximately 40% decrease).

“mRNA levels decreased approximately 40% between age 4-5 months (young) and 30-31 months (old) in ad libitum fed animals (p less than or equal to .05).”

Animalsad libitum feedingliverfemales

Influence of age and caloric restriction on expression of hepatic genes for xenobiotic and oxygen metabolizing enzymes in the mouse

Journal of gerontology·1 May 1991