Creatinine clearance

1. Age decreases creatinine clearance in humans (from 140 ml/min/1.73m2 at age 30 to 97 at age 80).

   “cross-sectional analysis by 10-year age groups showed a progressive linear decline in clearance from 140 ml/min/1.73m2 at age 30 to 97 at age 80.”

   Humansmales

   The effect of age on creatinine clearance in men: a cross-sectional and longitudinal study

   Journal of gerontology·1 Mar 1976

1. Framingham risk score is associated with creatinine clearance in humans (r = -0.459, P<0.001).

   “There was a significantly inverse correlation between FRS and GFR with Ccr having the Pearson correlation coefficient -0.586 (GFR(CG), P<0.001), - 0.449 (GFR(MDRD1) and GFR(MDRD2), P<0.001), -0.459 (Ccr, P<0.001).”

   Humansin healthy Chinese adultsn = 505

   The relationship between age-related kidney dysfunction and Framingham risk score in healthy people in China

   Current aging science·1 Dec 2010

More on Framingham risk score

1. Creatinine clearance predicts number of falls per person in humans.

   “Low CrCl less than 60 ml/min was a predictor of the number of falls per person but not fallers in the placebo group (P = 0.007).”

   Human trialin the placebo group3-yrfemales

   An age-related decrease in creatinine clearance is associated with an increase in number of falls in untreated women but not in women receiving calcitriol treatment

   The Journal of clinical endocrinology and metabolism·10 Oct 2006