Core macrophage gene expression signature

Age is associated with core macrophage gene expression signature in mice (35 consistently altered genes).

“Meta-analysis further defined a core set of 35 genes consistently altered with age across mouse macrophage populations”

Reviewacross mouse macrophage populationsmacrophagesmale and females

Mouse macrophages from diverse niches show generally divergent age-related transcriptional remodeling signatures

bioRxiv (Cold Spring Harbor Laboratory)·6 Feb 2026Preprint