What does the research say about complement component?

Complement component

There are 2 papers on complement component in aging research: 2 observational studies in people. The newest story, Oct 26, 2026: “Six proteins link branched-chain amino acids to heart disease”.

Biomarker

2 papers study it68 more mention it1 finding

5 new papers in 30 daysSee all 70 papers on complement component

“Moreover, C1-inhibitor, C5, C8, and C9 increased with age in contrast to a decrease of factor D and C3 levels.”

Age and Sex-Associated Changes of Complement Activity and Complement Levels in a Healthy Caucasian PopulationFrontiers in immunology2018doi:10.3389/fimmu.2018.02664

Humans2

Associations

Older age

mixedin humans1

1 study

Older age is associated with complement component in humans.
“Moreover, C1-inhibitor, C5, C8, and C9 increased with age in contrast to a decrease of factor D and C3 levels.”
Humansserumn = 120
Age and Sex-Associated Changes of Complement Activity and Complement Levels in a Healthy Caucasian Population
Frontiers in immunologyNov 20, 2018

Latest

22 papers in 12 months

Molecular Biology ReportsNov 12

Epigenetic regulation of the complement system in age-related chronic inflammation: mechanisms and therapeutic prospects

ReviewComplement system

Paper

Nutrition, Metabolism, and Cardiovascular DiseasesOct 29

Prenatal lifestyle associations with maternal and infant metabolic biomarkers: secondary analysis of the PEARS RCT

Cohort study of 334 peoplePopulations

Paper

iScienceOct 27

Hippocampal and hypothalamic cell-type specific mechanisms underlying nutritional and metabolic modulation of Alzheimer's disease

Experiments in miceInterventions

Paper

ESC Congress 2026 AbstractOct 26

Six proteins link branched-chain amino acids to heart disease

The six proteins accounted for 6.5% to 32.1% of the link between branched-chain amino acids and ischemic heart disease risk in a genetic analysis.The six proteins accounted for 6.5% to 32.1% of the link between branched-chain amino acids and ischemic heart disease risk in a genetic analysis.

Mendelian randomizationMechanisms

Paper

Frontiers in NutritionOct 15

Immune protein linked to frailty in colorectal cancer

An observational study of 100 people with colorectal cancer linked higher blood levels of an immune protein to more severe frailty.An observational study of 100 people with colorectal cancer linked higher blood levels of an immune protein to more severe frailty.

Cross-sectional · 100 peopleImmune response

Paper

bioRxivOct 9

Aging alters eye tissue proteins differently in mice

In an experiment comparing 73-week-old mice with 8-week-old mice, aging changed 85 proteins in the retina and 272 in the supporting eye tissue.In an experiment comparing 73-week-old mice with 8-week-old mice, aging changed 85 proteins in the retina and 272 in the supporting eye tissue.

Preprint: experiments in miceEye

Paper

Orthopedic ReviewsOct 1