Circulating α-Klotho

1 paper3 findings

Interventions

2

Physical activity

no changein humans1

1 study

Physical activity has no effect on circulating α-Klotho in humans.
“habitual physical activity showed no significant effect on α-Klotho compared to inactive controls (p = 0.25; I2 = 100%).”
Reviewcompared with inactive controls
Circulating α-Klotho and Multidimensional Aging and Frailty Outcomes: A Systematic Review and Meta-Analysis from the European Renal Association CKD-MBD Working Group
Calcified tissue international30 Apr 2026

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Exercise

upin humans1

1 study

Exercise increases circulating α-Klotho in humans (95% CI 93.93–261.73; units not stated).
“Exercise interventions increased circulating α-Klotho (95% CI: 93.93, 261.73, p < 0.0001; I2 = 89%)”
Review
Circulating α-Klotho and Multidimensional Aging and Frailty Outcomes: A Systematic Review and Meta-Analysis from the European Renal Association CKD-MBD Working Group
Calcified tissue international30 Apr 2026

More on Exercise

Associations

1

Frailty

downin humans1OR 0.61

1 study

Circulating α-Klotho is associated with frailty in humans (OR 0.61, 95% CI 0.49–0.77).
“higher circulating α-Klotho levels were significantly associated with lower odds of frailty (OR = 0.61, 95% CI: 0.49, 0.77; p < 0.0001, I2 = 0%).”
Review
Circulating α-Klotho and Multidimensional Aging and Frailty Outcomes: A Systematic Review and Meta-Analysis from the European Renal Association CKD-MBD Working Group
Calcified tissue international30 Apr 2026

Latest

2 in 12 months

Frontiers in Sports and Active Living18 Sep

Physical exercise and circulating α-Klotho in humans: a systematic review and meta-analysis with emphasis on older adults

Meta-analysis of randomised trialsResistance training

Calcified Tissue International30 Apr

Circulating α-Klotho and Multidimensional Aging and Frailty Outcomes: A Systematic Review and Meta-Analysis from the European Renal Association CKD-MBD Working Group

Meta-analysis of studies in peopleBiomarkers

Tobacco Induced Diseases28 Jul

Current marijuana use is associated with lower circulating α-Klotho levels in US adults even after adjusting for tobacco use: A national cross-sectional analysis of NHANES

Study in peopleBiomarkers

The Journals of Gerontology, Series A20 May

Higher Circulating Alpha-klotho Levels Increase All-cause Mortality Through Mediation Effects of Liver Fibrosis: A Second Analysis of National Health and Nutrition Examination Survey

Study in peopleBiomarkers

Rejuvenation Research3 Feb

Relationship of α-Klotho with Frailty Index and Sarcopenia: A Bidirectional Mendelian Randomization Study

Study in peopleMechanisms

GSA 2024 Abstract1 Jan

ASSOCIATION BETWEEN POLYPHARMACY AND Α-KLOTHO IN US OLDER ADULTS: THE MEDIATION ROLE OF INFLAMMATORY MARKERS

Cross-sectional study of 3,569 peoplePopulations

The American Journal of Pathology10 Feb

Circulating α-Klotho Counteracts Transforming Growth Factor-β-Induced Sarcopenia

Experiments in animalsMechanisms