Cheek mucosa DNA methylation profiles

1. Cheek mucosa DNA methylation profiles predict clinical laboratory biomarkers in humans.

   “Multiple clinical laboratory biomarkers could be predicted using cheek mucosa-derived methylation data, particularly after sex stratification, including inflammatory, metabolic, thyroid-related, and sex hormone-related markers.”

   HumansJapanese adultscheek mucosaboth; sex-stratified analysessn = 186

   Predicting Biological Age and Clinical Biomarkers from DNA Methylation Profiles of Cheek Mucosa

   bioRxiv (Cold Spring Harbor Laboratory)·14 May 2026Preprint

More on Clinical laboratory biomarkers

1. Cheek mucosa DNA methylation profiles predict Phenotypic Age in humans (R = 0.964).

   “Cheek mucosa-derived MSA methylation data enabled accurate prediction of chronological age (R = 0.965) and phenotypic age (R = 0.964) using the two-stage method.”

   HumansJapanese adults; two-stage residual learning methodcheek mucosan = 186

   Predicting Biological Age and Clinical Biomarkers from DNA Methylation Profiles of Cheek Mucosa

   bioRxiv (Cold Spring Harbor Laboratory)·14 May 2026Preprint

More on Phenotypic Age

1. Cheek mucosa DNA methylation profiles predict chronological age in humans (R = 0.965).

   “Cheek mucosa-derived MSA methylation data enabled accurate prediction of chronological age (R = 0.965) and phenotypic age (R = 0.964) using the two-stage method.”

   HumansJapanese adults; two-stage residual learning methodcheek mucosan = 186

   Predicting Biological Age and Clinical Biomarkers from DNA Methylation Profiles of Cheek Mucosa

   bioRxiv (Cold Spring Harbor Laboratory)·14 May 2026Preprint