Cerebrovascular responsiveness to hypercapnia

1. Aerobic exercise increases cerebrovascular responsiveness to hypercapnia in humans (98.5 ± 38.4% vs. 58.0 ± 42.0%, P = 0.021).

   “AT increased the CVR to hypercapnia (98.5 ± 38.4% vs. 58.0 ± 42.0%, P = 0.021)”

   Human trial16 weeks

   The Effects of Aerobic Exercise Training on Cerebrovascular and Cognitive Function in Sedentary, Obese, Older Adults

   Frontiers in aging neuroscience·May 18, 2022

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1. Resveratrol improves cerebrovascular responsiveness to hypercapnia in humans (R = -0.329, P = 0.014).

   “this was associated with improvements in cerebrovascular responsiveness to hypercapnia (R = -0.329, P = 0.014).”

   Human trial75 mg BID24-monthfemalesn = 125

   Long-term resveratrol supplementation improves pain perception, menopausal symptoms, and overall well-being in postmenopausal women: findings from a 24-month randomized, controlled, crossover trial

   Menopause (New York, N.Y.)·Aug 31, 2020

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1. Curcumin showed no clear effect on cerebrovascular responsiveness to hypercapnia in humans.

   “Curcumin did not significantly affect these outcomes either alone or in combination with fish oil.”

   Human trial16-week

   Effects of fish oil and curcumin supplementation on cerebrovascular function in older adults: A randomized controlled trial

   Nutrition, metabolism, and cardiovascular diseases : NMCD·Dec 30, 2019

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1. Fish oil showed no clear effect on cerebrovascular responsiveness to hypercapnia in humans.

   “The primary outcome, cerebrovascular responsiveness to hypercapnia, was not affected by the interventions.”

   Human trial16-weekn = 152

   Effects of fish oil and curcumin supplementation on cerebrovascular function in older adults: A randomized controlled trial

   Nutrition, metabolism, and cardiovascular diseases : NMCD·Dec 30, 2019

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