Cerebrovascular reactivity to carbon dioxide

1. Intermittent hypoxia has no effect on cerebrovascular reactivity to carbon dioxide in humans (P = 0.739).

   “However, compared with CTL, IHC did not significantly improve any CVRCO2 parameters”

   Human trialelderly individualsmiddle cerebral artery8 wkn = 18

   Moderate intermittent hypoxic conditioning to enhance cerebrovascular function in the elderly: a randomized controlled trial

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1. White matter hyperintensity volume decreases cerebrovascular reactivity to carbon dioxide in humans (CVRNAWM = 0.54 ± 0.48%; CVRWMH = 0.24 ± 0.94%; p = 0.006).

   “Yet, within individuals, CVR was lower inside WMHs compared to normal-appearing white matter (CVRNAWM = 0.54 ± 0.48%; CVRWMH = 0.24 ± 0.94%; p = 0.006).”

   Humanswithin individuals with white matter hyperintensitieswhite mattern = 200

   Relation between Cerebral Small Vessel Function at 7T MRI and Small Vessel Disease Burden in a General Aging Population

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