What does the research say about cerebral frailty risk score?

Cerebral frailty risk score

There are 2 papers on cerebral frailty risk score in aging research: 2 observational studies in people. The newest story, Nov 11, 2026: “Brain scans improve dementia risk ranking beyond frailty”.

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2 papers study it2 findings

1 new paper in 30 daysSee all 2 papers on cerebral frailty risk score

“Integrating the top 10 predictors into an integer-based CFRS achieved strong discriminatory performance (C-index = 0.843, iAUC = 0.808)”

Neural correlates of frailty and the development of a cerebral frailty risk score for dementiaGeroScience2026doi:10.1007/s11357-026-02635-8

Humans2

Associations

Incident dementia

upin humans1

1 study

Cerebral frailty risk score predicts incident dementia in humans (dementia-free participants) (C-index = 0.843, iAUC = 0.808).
“Integrating the top 10 predictors into an integer-based CFRS achieved strong discriminatory performance (C-index = 0.843, iAUC = 0.808)”
Humansdementia-free participants10 years52.3% femalesn = 63,509
Brain scans improve dementia risk ranking beyond frailty
GeroScienceNov 11, 2026

Latest

2 papers in 12 months

GeroScienceNov 11

Brain scans improve dementia risk ranking beyond frailty

A simplified score achieved 0.843 on a measure of risk ranking, while a fuller model outperformed frailty alone over 10 years.A simplified score achieved 0.843 on a measure of risk ranking, while a fuller model outperformed frailty alone over 10 years.

Cohort · 63,509 peopleIncident dementia

Paper

medRxivApr 4

A Cerebral Frailty Risk Score Integrating Frailty Index and Neuroimaging for Dementia Prediction in the UK Biobank

Preprint: cohort study of 63,509 peopleFrailty index