CD4+CD28-CD57+ T cells

1. Hemodiafiltration decreases CD4+CD28-CD57+ T cells in humans (3.8 (2.4-5.3) vs. 2.1 (1.3-3.3)%).

   “patients undergoing hemodiafiltration had a significantly decreased percentage of CD4+CD28-CD57- T cells [3.8 (2.4-5.3) vs. 2.1 (1.3-3.3)%, respectively, p = 0.002]”

   Humanscompared with hemodialysis

   Hemodiafiltration May Be Associated with Senescence-Related Phenotypic Alterations of Lymphocytes, Which May Predict Mortality in Patients Undergoing Dialysis

   International journal of molecular sciences·11 Oct 2024

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1. CD4+CD28-CD57+ T cells decrease age at death in humans (-0.54-year earlier death (95% CI: -0.87, -0.21)).

   “each SD higher proportion of CD4+CD28-CD57+ cells was associated with a 0.54-year earlier death (95% CI: -0.87, -0.21)”

   Humansbloodn = 1,625

   Association of Immune Cell Subsets With Longevity: The Cardiovascular Health Study

   The journals of gerontology. Series A, Biological sciences and medical sciences·16 May 2025

1. CD4+CD28-CD57+ T cells are associated with load-dependent pulse wave velocity in humans (β = 0.04 m/s, P < 0.01).

   “higher CD4+CD28−CD57+, but not CD8+CD28−CD57+, T-cells were associated with higher LD-PWV (β = 0.04 m/s, P < 0.01) after adjusting for covariates”

   Humansperipheral bloodn = 1,984

   Associations of circulating T-cell subsets with carotid artery stiffness: the multiethnic study of atherosclerosis

   American journal of physiology. Heart and circulatory physiology·26 Nov 2024

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