Aging Cell
Stem cell mix may help explain lower T cell output in aging mice
In lab-grown thymus models, individual mouse stem cells showed little, if any, age-related loss of T cell output within the same stem cell type.In lab-grown thymus models, individual mouse stem cells showed little, if any, age-related loss of T cell output within the same stem cell type.
Animal cell studyBlood and immune system
Who was studiedMouse bone marrow stem cells, against myeloid-biased stem cells
What changedLymphoid-biased stem cells had higher T cell potential than myeloid-biased cells, the predominant type in aged bone marrow
The catchT cell potential in organoids is a stand-in for production within an aging thymus