What does the research say about CCL17?

CCL17

There are 12 papers on CCL17 in aging research: 6 observational studies in people, 6 in animals. The newest story, Nov 12, 2026: “Immune signaling linked to cancer-drug heart inflammation”.

Biomarker

12 papers study it4 more mention it2 findings

2 new papers in 30 daysSee all 16 papers on CCL17

Humans6
Animals6

Interventions

Reg3γ

upin cells1

1 study

Reg3γ increases CCL17 in cells.
“RNA sequencing of recombinant Reg3γ-treated bone marrow-derived macrophages (BMDMs) revealed significant upregulation of CCL17”
Cellsrecombinantbone marrow-derived macrophage
Protein loss made irregular rhythms harder to trigger in mice
ESC Congress 2026 abstractOct 26, 2026

Associations

DNMT3A

upin mice1

1 study

DNMT3A is associated with CCL17 in mice (Dnmt3aR878H myeloid cells during ligature-induced periodontitis).
“Transcriptomic analysis revealed upregulation of Ccl17 in gingival R878H myeloid cells, which was corroborated by elevated serum and bone marrow levels of CCL17.”
AnimalsDnmt3aR878H myeloid cells during ligature-induced periodontitisgingiva, serum, and bone marrow
Ligature-induced periodontitis promotes Dnmt3aR878H-driven clonal hematopoiesis
HaematologicaJan 22, 2026

Latest

9 papers in 12 months

medRxivNov 12

Immune signaling linked to cancer-drug heart inflammation

An observational study enrolled 236 patients in cancer-related heart care, including 88 taking immune checkpoint inhibitors, and identified an inflammation-linked…An observational study enrolled 236 patients in cancer-related heart care, including 88 taking immune checkpoint inhibitors, and identified an inflammation-linked signaling pathway.

Preprint: cohort studyJAK–STAT signaling

Paper

ESC Congress 2026 AbstractOct 26

Protein loss made irregular rhythms harder to trigger in mice

Aging mice lacking the protein in heart muscle cells had reduced structural changes in the heart’s upper chambers and lower susceptibility to an experimentally triggered…Aging mice lacking the protein in heart muscle cells had reduced structural changes in the heart’s upper chambers and lower susceptibility to an experimentally triggered irregular heartbeat.

Mouse studyMechanisms