Brain age prediction

Biomarker

2 papers2 findings

  • Humans2

Upstream

1

Multiscale morphometrics

upin silico1

1 study
  1. multiscale morphometrics improve brain age prediction in silico (adjusted R2 boosted from 0.35 to 0.7).

    “In a proof-of-principle brain age prediction context, multiscale morphometrics provided additional predictive value, boosting the adjusted $R^{2}$ of the model from 0.35 to 0.7.”

    In silicobrain

    Multiscale cortical morphometry reveals pronounced regional and scale-dependent variations across the lifespan

    Cerebral cortex (New York, N.Y. : 1991)4 Jun 2025

Associations

1

Deep learning brain age model

mixedin silico1

1 study
  1. deep learning brain age model predicts brain age prediction in silico.

    “We found that the model directly generalized to the elderly participants, but model finetuning was necessary for children.”

    In silicoPreviously published model tested in Singaporean participantsbrain

    Rate of brain aging associates with future executive function in Asian children and older adults

    eLife7 Jun 2024Preprint

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Translational Psychiatry

Genetic risk and lifestyle linked to estimated brain aging

An observational study of 46,843 UK Biobank participants linked higher genetic risk and unhealthy lifestyles to faster aging estimated from brain scans.An observational study of 46,843 UK Biobank participants linked higher genetic risk and unhealthy lifestyles to faster aging estimated from brain scans.

Cohort study of 46,843 peopleBiomarkers
Research Square

Estimated brain-age gap rises by three years in pregnancy

Brain-age gap estimates rose by about three years during pregnancy and fell below pre-conception levels by 16 months postpartum in a longitudinal study.Brain-age gap estimates rose by about three years during pregnancy and fell below pre-conception levels by 16 months postpartum in a longitudinal study.

Preprint: cohort study of 340 peoplePopulations