BDNF methylation

1. Aerobic exercise increases BDNF methylation in humans.

   “Intervention effects were observed at four CpG sites: cg05189570, cg08382738, cg12067298, cg20340655.”

   Human trialbreast cancersix-monthfemalesn = 117

   Associations of BDNF methylation and rs6265 genotype with cognitive response to a six-month aerobic exercise intervention in women with early-stage breast cancer: results from the EPICC Trial

   GeroScience·18 Nov 2025

More on Aerobic exercise

1. RS6265 is associated with BDNF methylation in humans.

   “At pre-randomization, the additive T allele effect of rs6265 on methylation of cg10635145 and cg07238832 was detected.”

   Human trialpre-randomization

   Associations of BDNF methylation and rs6265 genotype with cognitive response to a six-month aerobic exercise intervention in women with early-stage breast cancer: results from the EPICC Trial

   GeroScience·18 Nov 2025

More on RS6265

1. BDNF methylation is associated with mental flexibility in humans (b = 0.373; p = 0.031).

   “cg06025631 (b = 0.373; p = 0.031) were correlated with attention and mental flexibility improvements, respectively.”

   Human trialbreast cancersix-monthfemalesn = 117

   Associations of BDNF methylation and rs6265 genotype with cognitive response to a six-month aerobic exercise intervention in women with early-stage breast cancer: results from the EPICC Trial

   GeroScience·18 Nov 2025

1. BDNF methylation is associated with attention in humans (b = 0.138; p = 0.049).

   “Methylation increases at cg05818894 (b = 0.138; p = 0.049) and cg06025631 (b = 0.373; p = 0.031) were correlated with attention and mental flexibility improvements, respectively.”

   Human trialbreast cancersix-monthfemalesn = 117

   Associations of BDNF methylation and rs6265 genotype with cognitive response to a six-month aerobic exercise intervention in women with early-stage breast cancer: results from the EPICC Trial

   GeroScience·18 Nov 2025