Artery proteomic age

1. Artery proteomic age raises the risk of coronary heart disease in humans (HR 1.22 (95% CI 1.13-1.31) per 5-year-higher age gap).

   “older arteries and hearts were associated with an increased risk for coronary heart disease (CHD; hazard ratio [HR] per 5-year-higher age gap, 1.22; 95% CI [1.13-1.31]”

   Humansarteryn = 11,757

   Biological organ ages associate with risk of chronic diseases in a community-based population

   JCI insight·8 Dec 2025

More on Coronary heart disease

1. Artery proteomic age is associated with heart failure severity in humans (OR = 1.10, 95% CI 1.01 to 1.18).

   “artery OAA was linked to HF only in women (OR = 1.10, 95% CI 1.01 to 1.18).”

   HumansHELPFul cohortfemales

   Proteome organ aging and cardiometabolic risk in a population at risk for heart failure

   Cardiovascular diabetology·12 Nov 2025