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Antigen-specific T-cell receptor DNA rearrangements

Biomarker

1 paper studies it1 finding

  • Animals1

Interventions

1

Disruptors of the sestrin-mapk immune-inhibitory complex

upin mouse cells1

1 study

  1. Disruptors of the sestrin-mapk immune-inhibitory complex induces antigen-specific T-cell receptor DNA rearrangements in mouse cells.

    “the DOS generated stem T cells present de novo antigen-specific T-cell receptor DNA rearrangements that precede their future expansion.”

    CellsDOS-generated stem T cellsT cell

    Disruptors of sestrin-MAPK interactions rejuvenate T cells and expand TCR specificity

    bioRxiv (Cold Spring Harbor Laboratory)Preprint

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