Disruptors of the sestrin-mapk immune-inhibitory complex

1. Disruptors of the sestrin-mapk immune-inhibitory complex induces antigen-specific T-cell receptor DNA rearrangements in mouse cells.

   “the DOS generated stem T cells present de novo antigen-specific T-cell receptor DNA rearrangements that precede their future expansion.”

   CellsDOS-generated stem T cellsT cell

   Disruptors of sestrin-MAPK interactions rejuvenate T cells and expand TCR specificity

   bioRxiv (Cold Spring Harbor Laboratory)·May 21, 2024Preprint

More on Antigen-specific T-cell receptor DNA rearrangements

1. Disruptors of the sestrin-mapk immune-inhibitory complex induces stem-like memory features in mouse cells.

   “generation of long-lived stem like memory features.”

   Cellssenescent T cellsT cell

   Disruptors of sestrin-MAPK interactions rejuvenate T cells and expand TCR specificity

   bioRxiv (Cold Spring Harbor Laboratory)·May 21, 2024Preprint

1. Disruptors of the sestrin-mapk immune-inhibitory complex improves T cell fitness in mouse cells.

   “increased T cell fitness, and generation of long-lived stem like memory features.”

   Cellssenescent T cellsT cell

   Disruptors of sestrin-MAPK interactions rejuvenate T cells and expand TCR specificity

   bioRxiv (Cold Spring Harbor Laboratory)·May 21, 2024Preprint

1. Disruptors of the sestrin-mapk immune-inhibitory complex induces sestrin-MAPK immune-inhibitory complex degradation in mouse cells.

   “which target sMAC to ubiquitin-dependent proteasomal degradation”

   CellsT cell

   Disruptors of sestrin-MAPK interactions rejuvenate T cells and expand TCR specificity

   bioRxiv (Cold Spring Harbor Laboratory)·May 21, 2024Preprint